ischemic stroke
Conditions
Interventions
experimental group:Routine rehabilitation+ccPAS
control group:Routine rehabilitation+sham ccPAS
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: a) diagnosis of an ischemic or hemorrhagic stroke by clinical evaluation and comprehensive imaging examination according to the definition of the International Classification of Diseases (ICD-10); b) Age between 40-70 years, regardless of gender; c) A primary stroke, 2 weeks to 6 months from the onset; d) A lesion distributed in the brain region supplied by middle cerebral artery (MCA), and accompanied by unilateral upper limb motor dysfunction, as indicated by computed tomography or magnetic resonance imaging; e) Right-handedness; f) Scoring over 27 by The Minimum Mental State Examination (MMSE); g) A written informed consent submitted.
Exclusion criteria
Exclusion criteria: a) A medical history of severe heart disease, liver disease, kidney disease or infectious disease; b) With severe cognitive, sensory, and emotional dysfunction; c) The lesion located in the bilateral cerebral hemisphere, cerebellum or brain stem; d) Apply drugs that change the excitability of the cerebral cortex (anti-epileptics, sedative and hypnotic drugs, etc.); e) Contraindications related to cortical stimulation and imaging: ·cardiac pacemaker ·metallic implant in the head ·mental illness or epilepsy ·History of syncope with unknown etiology ·uncontrolled arrhythmias or unstable hearth diseases f) Women during pregnancy or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FMA-UE; | — |
Secondary
| Measure | Time frame |
|---|---|
| action research arm test, ARAT;modified Barthel index;motor evoked potential, MEP;Resting motor threshold, RMT;Quantitative diagnostic criteria for stroke syndrome;Remodeling of neural circuits in functional MRI; | — |
Countries
China
Contacts
Public ContactJiajia Wu
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed