colorectal cancer
Conditions
Interventions
Surgical treatment group:surgical resection of primary tumor+ chemotherapy
non surgical treatment group:chemotherapy
Sponsors
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years, both gender. 2. ECOG:0-1 score. 3. Expected survival time > 6 months. 4. Pathological confirmed colon cancer or rectal cancer. 5. Measurable metastatic lesion. 6. CT,MRI,or PET-CT confirmed metastasis. 7. MDT confirmed unresectable metastasis lesion. 8. No evidence of obstruction, bleeding, perforation. 9. WBC >= 4.0 * 10^9/L, Neu >= 2.0 * 10^9/L, PLT >= 100 * 10^9/L ,TBIL < 1.0 * ULN AST < 2.5 * ULN, ALT < 2.5 * ULN , SCR < 1.5ULN. 10. No history of chemotherapy.
Exclusion criteria
Exclusion criteria: 1. Colorectal perforation, bleeding and obstruction requiring operation. 2. Multipleprimary coloreetal carcinoma. 3. Peritoneal metastasis. 4. Uncontrollable Pleural fluid. 5. History of other malignant tumor in 5 years. 6. Brain metastasis. 7. Pregnant or lactating women or women of childbearing age who refuse to accept contraception. 8. Drug addiction. 9. Severe heart, liver, kidney damage or other serious uncontrolled medical illness or acute infection, cachexia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS; | — |
Countries
China
Contacts
Public ContactZhongchuan Wang
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed