spontaneous intracerebral hemorrhage
Conditions
Interventions
experimental group:ICP monitoring treatment
control group:Conventional treatment
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years but <= 70 years; 2. Supratentorial spontaneous intracerebral hemorrhage with or without IVH confirmed by head CT; 3. Admission within 12 hours of onset, GCS score of 5-12 on admission or GCS score decreased to < 12 within 24 hours of admission; 4. INR < 1.4; 5. No contraindications for ICP monitoring and the randomized grouping could be completed within 6 hours after admission or within 6 hours after the score dropped to the inclusion criteria.
Exclusion criteria
Exclusion criteria: 1. Patients with spontaneous cerebellar or brainstem hemorrhage or only intraventricular hemorrhage; 2. Patients with GCS score of 3-4 or bilateral pupil fixation; 3. Evidence that spontaneous intracerebral hemorrhage is caused by secondary causes, such as arteriovenous malformation, intracranial aneurysm, cerebral infarction, tumor or trauma, etc.; 4. Patients with previous brain diseases with neurological deficits or disturbance of consciousness; 5. Patients with life expectancy less than 3 days after onset of disease; 6. Pregnancy, childbirth or lactation within 30 days; 7. Taking new anticoagulants (e.g. dabigatran) within 48 hours; 8. Platelet < 50000 / mm3; 9. Patients whose family members did not agree to be included in the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GOSE at 90 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| mRS at 90 days; | — |
Countries
China
Contacts
Public ContactHu Jin
Huashan Hospital, Fudan University
Outcome results
None listed