Idiopathic pulmonary fibrosis
Conditions
Interventions
Experimental group:Bronchoscopic infusion of self repairing airway epithelial cells
Control group:Conventional therapy
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. According to the IPF diagnostic criteria issued by the American Thoracic Society and the European Respiratory Association in 2018, the clinical manifestations were progressive dyspnea, ventilation dysfunction with decreased diffusion function, hypoxemia and diffuse lung lesions on imaging. FVC > 50% predicted value, DLCO > 30% predicted value. Lung histology and high resolution CT (HRCT) showed common interstitial pneumonia (UIP); 2. 40-65 years old, both male and female; 3. Good compliance, mental health, can cooperate with clinical observation; 4. No complications (diabetes, acute infection, hyperthyroidism, heart failure, hepatitis, nephritis); 5. There are evaluable lesions that can be found by CT; 6. Fully informed of the purpose, method and possible discomfort of the clinical research, agreed to participate in the clinical study, and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who can't tolerate cell therapy; 2. Patients with obvious pulmonary infection requiring anti infection treatment (respiratory tract infection and systemic infection within 4 weeks before treatment); 3. Patients with malignant tumor; 4. Participants in other drug trials 3 months before enrollment; 5. Patients severe systemic diseases and other organ dysfunction; 6. Pregnant women, lactating women or those who have family planning recently and cannot take effective contraceptive measures; 7. Patients with obvious abnormal liver and kidney function (ALT > 1.5 times of upper limit of normal value; Cr > 1.5 times of upper limit of normal value); 8. People who are not suitable for the selection through The researchers assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary function; | — |
Secondary
| Measure | Time frame |
|---|---|
| High resolution computed tomography;Arterial partial pressure of oxygen;6-minute walk test;St George's score;Treatment endpoint events;Receptor for advanced glycation endproducts;Angiopoietin 2, ANGPT2;Biomarkers; | — |
Countries
China
Contacts
Public ContactTao Ren
Shanghai Sixth People's Hospital
Outcome results
None listed