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Left Dlpfc-rTMS combined with CIMT improves upper limb function after stroke and its mechanism

Left Dlpfc-rTMS combined with CIMT improves upper limb function after stroke and its mechanism

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000036646
Enrollment
Unknown
Registered
2020-08-24
Start date
2021-01-01
Completion date
Unknown
Last updated
2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyskinesia after stroke

Interventions

1:constraint-induced movement therapy ( CIMT
2:Repetitive transcranial magnetic stimulation(rTMS)
3:rTMS+CIMT

Sponsors

North Hospital of Huashan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. It was the first subcortical stroke; 2. hemiplegia was present, and the Brunnstrom grade of the affected side was no less than grade IV; and 3. the modified Ashworth scale was used to evaluate the muscle tension of the affected side, MAS) = 53 points or HAMD >= 8 points; 8. informed of the research and voluntarily signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Bone, joint and muscle diseases; 2. other serious nervous system diseases; 3. severe heart, lung, liver and kidney dysfunction; 4. epilepsy; 5. severe spasm or pain; 6. severe speech, attention, hearing, vision, sensory, intelligence, mental or cognitive impairment (MMSE > 24 / 30 points); 7. history of malignant tumor diseases; and 8. metal objects or magnetic films, cardiac pacemakers, medical implants in the head Such as cardiac lead, central venous catheter

Design outcomes

Primary

MeasureTime frame
Action Research Arm Test, ARAT;Fugl-Meyer Assessment, FMA;

Secondary

MeasureTime frame
Wolf motor function test, WMFT;Brunnstrom;Barthel Index, BI;Self-rating Depression Scale, SDS; Hamilton Depression Scale, HAMD;fNIRS-HbO2;DTI-FA;

Countries

China

Contacts

Public ContactYan Hua

North Hospital of Huashan Hospital, Fudan University

1521051653@qq.com+86 17321207620

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026