Alzheimer's disease
Conditions
Interventions
Sponsors
Renji Hospital, School of Medicine, Shanghai Jiaotong University
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Aged 50-75 years; 2) Main complaints of memory decline, in line with SCD questionnaire 1-5 standards; 3) MMSE >= 20 points; 4) Education years >= 6 years; 5) Able to cooperate with a full set of neuropsychological examinations; 6) Sign informed consent.
Exclusion criteria
Exclusion criteria: 1) Meet the VASCOG diagnostic criteria of vascular cognitive impairment; 2) Definite diagnosis of other diseases that may cause cognitive impairment, such as Parkinson's disease, normal pressure hydrocephalus, vitamin B12 deficiency, hypothyroidism, etc. 3) Severe mental illness; 4) Severe depression: HDRS17 item score >= 24 points; 5) Severe heart, liver, kidney and other important organ diseases; 6) There is contraindication to PET-CT or cranial MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma p-Tau 217;plasma p-Tau 181;Aß amyloid;Pathologic Tau;SEN, SPE, ACC, AUC of ROC, PPV, NPV; | — |
Secondary
| Measure | Time frame |
|---|---|
| MRI burden score of CSVD;retinal microvascular abnormalities;Cognitive;Blood biochemical index; | — |
Countries
China
Contacts
Public ContactXu Qun
Renji Hospital, School of Medicine, Shanghai Jiaotong University
Outcome results
None listed