pre-eclampsia
Conditions
Interventions
control group:take 5g medical food stick containing placebo
Experimental group:take medical food stick containing 5g L-arginine
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1) Han women; 2) single pregnancy; 3) 24 weeks before the establishment of birth examination card; 4) can obtain the delivery outcome information; 5) age range: 18-50 years old; 6) have one or more of the following high-risk factors: first pregnancy, aged >= 40 years, pregnancy interval more than 10 years, body mass index >= 35 kg / m2, polycystic ovary syndrome, family history of PE, multiple pregnancy, women with kidney donation, 15 weeks of pregnancy The results showed that the average arterial pressure was higher than or equal to 4000g, the family history of coronary heart disease, and the current vaginal bleeding during pregnancy was more than 5 days.
Exclusion criteria
Exclusion criteria: Patients with pregnancy history of PE or hypertension, chronic kidney disease, chronic hypertension, diabetes (type 1 or 2), autoimmune diseases (including systemic lupus erythematosus or antiphospholipid syndrome), cancer or family history (cancer of first-degree relatives), and patients requiring long-term medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of preeclampsia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety index;Incidence of gestational hypertension;Incidence of severe preeclampsia;Incidence of adverse maternal and infant outcomes;The levels of L-arginine in plasma were measured;The levels of L-arginine in placenta were measured;The levels of Nitric oxide in serum were measured;The levels of Nitric oxide in placenta were measured; | — |
Countries
China
Contacts
Public ContactLi Wang
Shanghai General Hospital
Outcome results
None listed