deaf
Conditions
Interventions
Gold Standard:Reference Standard:
1?The original capture platform captures fetal cells: Anti-Fetal erythrocyte HbF antibody positive anti-erythrocyte GPA antibody positive
2?STR analysis and the gene mutant between fetal cells and parents.
Index test:Core 
technology 
of 
diagnosis 
for 
deafness: 
biomimetic 
nucleated 
blood 
cell 
detection 
(Anti-Fetal 
HbF 
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
Female
Age
25 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1) The proband identified the deaf mutation of GJB2 or SLC26A4; 2) The spouses identified the conflited genotype of deafness gene; 3) The spouses identified as carrier of GJB2 or SLC26A4.
Exclusion criteria
Exclusion criteria: 1) The pregnant herself has abnormal chromosome number and structure; 2) The pregnant had exogenous transfusion, stem cell transplantation, immunotherapy within 1 year; 3) The pregnant women had cancer; 4) The pregnant who are unable to complete prenatal diagnosis as required; 5) The multiple pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactJiang Yi
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed