hilar Cholangiocarcinoma
Conditions
Interventions
Group 1:biliary stent with intracavitary irradiation
Group 2:External Beam Radiotherapy Combined With Expandable Metallic Stent
Sponsors
The Third Affiliated Hospital of Naval Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 80 years; 2. Biliary obstruction caused by hilar cholangiocinoma; 3. Symptoms such as jaundice related to biliary obstruction; 4. Unresectability or refusal to be surgically treated; 5. The expected overall survival is more than 3 months; 6. Willing and able to comply with the study procedures and provide written informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Patients with suspected benign bile duct stricture; 2. Biliary tract stricture that could not be dilated enough to pass the delivery system; 3. Perforation of any ducts within the biliary tree; 4. HCC has received chemotherapy, radiotherapy, targeted drugs, PD1 and other anti-tumor therapy; 5. Presence of metallic biliary stent or bile duct surgery; 6. Percutaneous transhepatic cholangiography (PTC) procedure was contraindicated; 7. Active hepatitis orsclerosing cholangitis; 8. Intrahepatic metastases that extensively involves both lobes of the liver; 9. Uncontrolled hepatic encephalopathy, hepatorenal syndrome, ascites; 10. Active bleeding or abnormal coagulation function, has bleeding tendency or is receiving thrombolytic, anticoagulant or antiplatelet therapy; 11. Uncooperative or could not provide authorization and signature; 12. Any reason that researcher does consider its not possible to enroll.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| patency time of stent; | — |
Countries
China
Contacts
Public ContactHuang Jian
Outcome results
None listed