Leptomeningeal cancer
Conditions
Interventions
Gold Standard:1. pathology of primary lesion of tumor
2. Immunohistochemical staining of cerebrospinal fluid cytology
3. Flow cytometry for cerebrospinal fluid
4. High clinically suspect of condition
detection 
model 
based 
on 
deep 
neural 
and 
diagnosis 
Sponsors
Huashan Hospital North, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years; 2. Patients who have indications for lumbar puncture and successfully completed the assay of cerebrospinal fluid cytology; 3. With or without more than one symptom of Leptomeningeal cancer, such as headache, vomiting, mental state change, cognitive impairment, seizures, hemiplegia, gait instability, etc., indicating clinically conditions of leptomeningeal cancer; 4. Clinical conditions of infectious meningitis (bacterial, viral, tuberculosis, etc.); 5. Clinical conditions of immune-mediated non-infectious encephalomyelitis; 6. Increased cerebrospinal fluid cells due to unknown reasons.
Exclusion criteria
Exclusion criteria: 1. Patients who refuse to sign informed consent; 2. Patients who cannot tolerate lumbar puncture; 3. Patients who have failed multiple lumbar punctures; 4. Patients who have conditions of leptomeningeal cancer after treatment with radiotherapy and chemotherapy; 5. Without immunohistochemistry, flow cytometry, or biopsy pathology, leptomeningeal cancer cannot be ruled out; 6. The quality of cerebrospinal fluid cytology smear is not up to standard; 7. The cerebrospinal fluid cell count is lower than 5/µL.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy;SEN, SPE, AUC of ROC; | — |
Countries
China
Contacts
Public ContactMing Guan
Huashan Hospital North, Fudan University
Outcome results
None listed