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Clinical study on optimal strategy for treatment of Non-active Graves ophthalmopathy

Clinical study on optimal strategy for treatment of Non-active Graves ophthalmopathy

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000036591
Enrollment
Unknown
Registered
2020-08-24
Start date
2020-10-01
Completion date
Unknown
Last updated
2020-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Graves ophthalmopathy

Interventions

Sponsors

Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Typical ocular symptoms; 2. Protrusion degree & GT;18mm(including unilateral protruding eye); 3. Inactive protrusion is defined as the clinical scoring standard recommended by the 2008 Chinese Guidelines for the Diagnosis and treatment of thyroid diseases; 4. Refuse operation patients; 5. Patients with Graves' disease and normal serum thyroid hormone levels (FT3 and FT4) for at least two months; 6. Informed consent, willing to receive treatment and with good predictive compliance, age 18-70 years old; 7. TCM syndrome differentiation indicates deficiency of Yang qi and blockage of phlegm and blood stasis.

Exclusion criteria

Exclusion criteria: 1. Shortness of eyes caused by other causes: case of shortness of eyes, orbital inflammatory pseudotumor, carotid cavernous fistula or dural cavernous sinus short circuit, extraocular muscle lymphoid tumor, primary orbital tumor, eye metastasis tumor, intracranial tumor and other diseases. 2. Clinical score of protruding eye activity >= 3. 3. Psychopaths. 4. Patients with severe primary and secondary diseases such as cardiovascular, cerebrovascular, liver, kidney and hematopoietic systems, and with a tendency of hyperthyroidism crisis. 5. Women who are pregnant or breastfeeding.

Design outcomes

Primary

MeasureTime frame
proptosis;

Secondary

MeasureTime frame
TCM syndrome score;vision;Orbital computed tomography;

Countries

China

Contacts

Public ContactHong Li

Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine

shanhongli@126.com+86 188221186989

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026