solid pulmonary nodule
Conditions
Interventions
Index test:correlation 
and 
maging 
parameters(IVIM-DWI(D, 
D*?f)
DCE-MRI(TIC 
type?T1 
mapping?iAUC?Ktrans?Kep?Ve?TTP?MAX 
Conc?MAX 
Slope)?PET-CT(SUVmean?SUVmax?SUVmin?MTV?TLG))
Sponsors
Shanghai Chest Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.pulmonary nodules which is difficult to diagnose on CT: without any significant characteristics of malignancy or benignancy on CT imaging, for example, fat, harsh calcification, lobulation, bubble-like lucency and pleural indentation; 2.8mm <= tumor diameter <= 30mm; 3.no claustrophobia; 4.without hypersensitive to contrast agent; 5.liver and kidney function can afford the application of contrast agent; 6.without severe cardiorespiratory insufficiency or organ dysfunction; 7.patients can complete all of the imaging examinations; 8.without contraindication of MRI scanning; 9.patients undergo surgery or follow-up CT finds the tumor vanish, diminish, or stable for at least two years; 10.volunteer and sign an informed consent.
Exclusion criteria
Exclusion criteria: 1. Typical characteristics be found on CT imaging; 2. tumor diameter <= 8mm, which might not be found on MRI sequences; 3. the location of the nodule which is liable to cause motion artifact: close to heart or aorta; 4. any serious abnormalities such as cardiovascular diseases, organ or system dysfunction; 5. abnormality of CBC, liver and Kidney Function; 6. pregnant woman or to be pregnant female patient; 7. active B or C type hepatitis; 8. carriers of HIV; 9. any other current malignancy or malignancy history; 10. contraindication of MRI scanning.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| benignancy/malignancy;SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactYe Xiaodan
Shanghai Chest Hospital
Outcome results
None listed