gestational diabetes mellitus
Conditions
Interventions
experimental group:Fermented fiber, 20g / day (10g / time, twice a day), for 5 weeks
control group:Unfermented fiber, 20g / day (10g / time, twice a day), for 5 weeks
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Pregnant women with GDM high-risk factors were selected from October 2020 to May 2022 in our hospital obstetric outpatient card and regular prenatal examination. inclusion criteria: 1) Han women; 2) single pregnancy; 3) establishment of birth card before 20 weeks; 4) 75g oral glucose tolerance test (OGTT), serum insulin and glycosylated hemoglobin (A1C) were conducted at 24-28 weeks of pregnancy, HbA1c); 5) one or more of the following risk factors: older than 35 years old, overweight or obesity before pregnancy (BMI>25kg/m2), polycystic ovary syndrome, family history of diabetes, history of unexplained Intrauterine fetal death, stillbirth and abortion, history of fetal malformation, history of polyhydramnios, history of macrosomia, history of GDM, history of polyhydramnios, history of recurrent vulvovaginal candidiasis and the fetal development is greater than gestational age.
Exclusion criteria
Exclusion criteria: 1. Pre pregnancy diabetes mellitus (PGDM): including diabetes mellitus diagnosed before pregnancy, abdominal blood glucose = 7 mmol / L during the first prenatal examination, 75g OGTT for the first time, 2-hour postprandial blood glucose = 11.1mmol/l, typical hyperglycemia and hyperglycemia crisis symptoms, and at the same time, any blood glucose = 11.1mmol/l, glycosylated hemoglobin = 6.5% at the time of the first labor examination; 2. reproductive medicine means Pregnant women, including but not limited to in vitro artificial pregnancy, drug ovulation and other means; 3. chronic infectious diseases due to long-term use of antibiotics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of GDM; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of insulin resistance;Incidence of adverse maternal and infant outcomes;Poor glycemic control; | — |
Countries
China
Contacts
Public ContactXianming Xu
Shanghai General Hospital
Outcome results
None listed