Effect of oral anticoagulants on the prevention of stroke following left atrial appendage resection/clamping in patients with nonvalvular atrial fibrillation

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000036560

Enrollment

Unknown

Registered

2020-08-24

Start date

2020-10-01

Completion date

Unknown

Last updated

2020-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atrial fibrillation

Interventions

experimental group:Stop oral anticoagulants

control group:Continue oral anticoagulants

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) Patients with non-valvular atrial fibrillation after left atrial appendage resection/clipping (regardless of whether sinus rhythm can be maintained); 2) Provide an informed consent form that is willing to participate in research, follow-up trials and evaluation procedures; 3) Patient aged 18-80 years.

Exclusion criteria

Exclusion criteria: 1) Patients with coronary heart disease need to receive oral anticoagulant treatment; 2) Patients with atherosclerosis require oral anticoagulant treatment; 3) Patients with deep vein thrombosis or pulmonary artery thrombosis need oral anticoagulant treatment; 4) Other diseases need to be treated with oral anticoagulant drugs; 5) There are other bleeding diseases, and anticoagulation treatment cannot be performed; 6) Combined with cerebrovascular malformations; 7) Combined with abnormal coagulation function or blood system disease; 8) Past neurosurgery history; 9) Patients with uncontrolled cancer; 10) The anteroposterior diameter of the left atrium is greater than 60mm or the left ventricular ejection fraction is less than 30%; 11) Obvious liver and kidney function damage (and/or ALT and AST are higher than 1 times the upper limit of normal, CCr<50%); 12) Women who are pregnant, breastfeeding, planning to become pregnant, or women of childbearing age who have not adopted reliable contraceptive methods.

Design outcomes

Primary

Measure	Time frame
Morbidity of stroke;	—

Secondary

Measure	Time frame
TIA;bleeding;heart rate;rhythm;blood pressure;Systemic embolism;Rehospitalization rate;Cardiovascular death;	—

Countries

China

Contacts

Public ContactNan Ma

Xinhua Hospital, School of Medicine, Shanghai Jiaotong University

manancts@sina.com+86 13764530167

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026