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Comparison of left bundle branch pacing and biventricular pacing in the treatment of chronic systolic heart failure with left bundle branch block: a multicenter, prospective, randomized, controlled trial

Comparison of left bundle branch pacing and biventricular pacing in the treatment of chronic systolic heart failure with left bundle branch block: a multicenter, prospective, randomized, controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000036554
Enrollment
Unknown
Registered
2020-08-24
Start date
2020-10-01
Completion date
Unknown
Last updated
2024-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure

Interventions

Group 2:biventricular pacing

Sponsors

Zhongshan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age 18 to 80 years; 2. Sinus rhythm, complete LBBB meeting Strauss’s standard definition; 3. Left ventricular ejection Fraction 1 year; 5. The residence is stable and can meet the requirements of follow-up during the study period.

Exclusion criteria

Exclusion criteria: 1. decline to participate or refuse to sign the written informed consent; 2. pregnant or planning to become pregnant; 3. participate in other clinical studies; 4. patients with mechanical tricuspid valve implantation; 5. persistent or permanent atrial fibrillation; 6. heart transplant patients or patients waiting for heart transplantation; 7. Patients with severe renal dysfunction of blood creatinine>2.5mg/dl or>275umol/L or glomerular filtration rate <= 30 ml/min/1.72m^2 within 30 days prior to enrollment; (9) Patients with severe liver dysfunction of liver function exceeding three times the upper limit of normal values in the five liver function items within 30 days before enrollment.

Design outcomes

Primary

MeasureTime frame
Composite outcome of all-cause mortality and heart failure hospitalization;

Secondary

MeasureTime frame
Outcome of all-cause mortality;Outcome of heart failure hospitalization;Echocardiographic response/super-response rate;

Countries

China

Contacts

Public ContactSu Yangang

Zhongshan Hospital, Fudan University

su.yangang@zs-hospital.sh.cn+86 137 6130 0064

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 12, 2026