Alport syndrome
Conditions
Interventions
Gold Standard:Renal biopsy, skin biopsy and genetic test.
a 
test
Sponsors
Children's Hospital of Shanghai
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for patients in the experimental group: children with Alport syndrome were definitely diagnosed in our hospital, and the diagnostic criteria were as follows: A. A clear family history; B. Hematuria or proteinuria; C. GBM thickness imbalance or fracture appeared in renal biopsy electron microscope; D. Accompanied by hearing or eye damage. The normal children with no difference in age and gender were selected as the normal control group. 2. Inclusion criteria for children in the hematuria group: Children with clinical diagnosis of hematuria with no difference in age or gender in the same period were selected as the hematuria control group. The diagnostic criteria for hematuria was >= 3 red blood cells per high power microscopic field of vision in centrifugal-precipitated urine.
Exclusion criteria
Exclusion criteria: 1. Urinary tract infection; 2. urinary calculi and tumors; 3. vascular malformation and trauma; 4. systemic hemorrhagic disease; 5. kidney disease with rash, joint pain and other complications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urine IV collagen a chain;SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactXinyu Kuang
Children's Hospital of Shanghai
Outcome results
None listed