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A clinical study on the detection of circulating tumor cells based on antibody-independent nanotechnology to evaluate the efficacy and prognosis of recurrent liver cancer after ablation

A clinical study on the detection of circulating tumor cells based on antibody-independent nanotechnology to evaluate the efficacy and prognosis of recurrent liver cancer after ablation

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000036537
Enrollment
Unknown
Registered
2020-08-24
Start date
2020-10-01
Completion date
Unknown
Last updated
2020-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carcinomas, Hepatocellular

Interventions

Case series:RFA

Sponsors

South Branch of Renji Hospital, Shanghai JiaoTong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. For the first time were radical excision surgery, postoperative HCC diagnosed by pathological examination, cut edge negative, and residual liver left no residual carcinoma; 2. Liver function for the Child Pugh, grade A or B; 3. Confirmed by CT or MRI and other imaging examination for intrahepatic recurrence; 4. It is suitable for ablation treatment; 5. normal bone marrow reserve function in patients with line of ablation and normal liver kidney function.

Exclusion criteria

Exclusion criteria: 1. Clear distant metastasis of liver cancer or other malignant bile duct cell cancer of the liver; 2. had received radiation therapy for primary tumor or lymph node; 3. had received antitumor biological target therapy; 4. had received chemotherapy or immunotherapy for primary tumors; 5. Patients are being treated or had been treated with molecular targeted drugs such as sorafenib or TACE before operation; 6. Has serious coagulation dysfunction; 7. Combined with tumor thrombus from main portal vein to secondary branch, hepatic vein tumor thrombus, adjacent organ invasion or distant metastasis.

Design outcomes

Primary

MeasureTime frame
circulating tumor cells;PFS;

Secondary

MeasureTime frame
Objective response rate;Clinical benefit rate;Overall survival;Quality of life;

Countries

China

Contacts

Public Contactjinhua jiang

South Branch of Renji Hospital, Shanghai JiaoTong University School of Medicine

scarli8880@126.com+86 18019211138

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026