femoral head necrosis
Conditions
Interventions
control group:Peg /plga-ha particles enriched in stem cells were implanted without prp sustained release
experimental group:Implanting prp-peg/plga-ha scaffold rich in stem cells, containing prp sustained release
Sponsors
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
20 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Those aged 20-55; 2. Patients with avascular necrosis of femoral head in ARCO stage I- IIIA; 3. All patients volunteered to participate in this experiment, read and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Malignant bone tumors, bone and joint tuberculosis, and bone and joint damage caused by various infectious diseases; 2. The general condition is poor, and the functions of important organs such as heart, lung, brain and kidney and hematopoietic function are seriously damaged; 3. Those who have mental and neurological diseases cannot cooperate with treatment; 4. Those who have recently received bone growth factors such as BMP; 5. Patients who have recently received radiotherapy, chemotherapy, immunosuppressive agents and anticoagulants; 6. Allergic constitution or allergic to materials and reagents related to disease treatment; 7. Pregnant and lactating women; 8. Patients who are participating in other clinical research projects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Repair area of femoral head necrosis area;Growth of trabecular bone in necrotic area of femoral head;Physical examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| Harris; | — |
Countries
China
Contacts
Public ContactYuanqing Mao
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed