Repair of critical bone defect with enhanced bone marrow combined with individualized artificial bone scaffold combined with membrane induction technology

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000036529

Enrollment

Unknown

Registered

2020-08-24

Start date

2020-10-01

Completion date

Unknown

Last updated

2020-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critical bone defect

Interventions

control group:Autogenous bone graft

Experimental group:Bone transplantation with enhanced bone marrow combined with individualized artificial bone scaffold

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. The diagnosis was in accordance with the critical bone defect of extremities; 2. the age ranged from 18 to 70 years (including), with no gender limit; 3. able to understand the research protocol, voluntarily participate in the study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Bone and joint damage caused by malignant bone tumor, bone and joint tuberculosis, and various infectious diseases; 2. Patients with poor general condition and severe impairment of functions of important organs such as heart, lung, brain, kidney and hematopoiesis; 3. Patients with mental and neurological diseases unable to cooperate with treatment; 4. Patients who have received bone growth factor therapy such as BMP within 3 months; 5. Patients who have received radiotherapy, chemotherapy and immunosuppressant treatment within 3 months; 6. Allergic constitution or allergic to materials and reagents related to disease treatment; 7. Pregnant and lactating women; 8. Patients who have participated in other clinical research projects within 3 months; 9. Patients with bone metabolic diseases that may affect bone healing (such as hypoparathyroidism / hyperthyroidism, hypothyroidism / hyperthyroidism, hypophysis, hyperprolactinemia, Cushing's syndrome, acromegaly, Paget's disease, etc.) Other 10. Researchers think that patients who are not suitable for this study, such as poor autonomous behavior ability, poor expected compliance, and difficult to follow up according to the program requirements.

Design outcomes

Primary

Measure	Time frame
Bone healing time;	—

Countries

China

Contacts

Public ContactFengxiang Liu

Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine

liu_fengxiang@126.com+86 13901849351

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026