PCOS
Conditions
Interventions
experimental group:Application of low-molecular-weight heparin with estrogen-progestin therapy during embryo implantation period
control group:Application of estrogen-progestin therapy during embryo implantation period
Sponsors
International Peace Maternity and Child Health Hospital affiliated to Shanghai Jiao Tong University, School of Medicine
Eligibility
Sex/Gender
Female
Age
20 Years to 38 Years
Inclusion criteria
Inclusion criteria: 1. Chinese women aged between 20 and 38 years; 2. Meet Rotterdam PCOS standard diagnosis; 3. No IVF history, and it is planned to perform assisted fertility technology in this research unit; 4. Willing to cooperate with the research plan and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Other causes of hyperandrogen, such as thyroid disease congenital adrenal cortical hyperplasia; 2. A history of three or more miscarriages, or combined with immunogenic infertility; 3. Combined with severe male sterility and immune infertility; 4. Presence of uterine lesions: uterine malformation,adenomyosis,submucosal myoma or uterine adhesions; 5. Unilateral ovariectomy history; 6. Chromosomal abnormalities and need to undergo PGT; 7. Contraindications to assisted reproduction; 8. Contraindications to estrogen-progestin therapy or the use of low-molecular-weight heparin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ongoing pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| live birth rate;premature delivery;pregnancy complications;embryo loss rate; | — |
Countries
China
Contacts
Public ContactDandan Wu, Xianhua Lin
International Peace Maternity and Child Health Hospital affiliated to Shanghai Jiao Tong University, School of Medicine
Outcome results
None listed