Subclinical interstitial lung disease
Conditions
Interventions
B2:N-acetylcysteine (600 mg / time, 2 times / day until the end of the study)
B3: oral vitamin D (5000iu / week until the end of the study)
B1:Nil
Sponsors
Shanghai Chest Hospital
Eligibility
Sex/Gender
Male
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The patients with more than 5% lung field changes on imaging, including ground glass opacity, reticular abnormalities, diffuse central lobular nodules, non emphysematous cysts, honeycomb lung and tractive bronchiectasis; 2. Patients aged 45-85 years.
Exclusion criteria
Exclusion criteria: 1. The patients with connective tissue diseases and a clear history of dust and metal exposure, their relatives have familial idiopathic pulmonary fibrosis; 2. Patients with other system history, such as hypertension, diabetes, mental disorder, viral hepatitis and HIV (confirmed by test within 3 months); 3. Women who are pregnant or may be pregnant, and women in lactation period; 4. Patients who have participated in clinical trials or are participating in other clinical trials within one month; 5. Patients with frequent changes in living environment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of indoor and outdoor air pollution;Chest CT; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary function;King's Brief Interstitial Lung Disease (KBILD);KL-6;SP-D;MMP-7;1, 25(OH)2D3;8-OHd;MDA; | — |
Countries
China
Contacts
Public ContactLi Feng
Shanghai Chest Hospital
Outcome results
None listed