Rectal cancer
Conditions
Interventions
Experimental group:transanal total mesorectal excision
Sponsors
The First Affiliated Hospital of Naval Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Aged 18-80 years old; 2) Colonoscopy examines the lower edge of the tumor within 2-8 cm from the dentinal line, and biopsy pathology confirms rectal adenocarcinoma; 3) No distant transfer; 4) No other multiple primary cancers; 5) Preoperative CT or MRI or B-ultrasound in the rectal below T3 (not including T3), the tumor can be removed; 6) Possess sufficient organ function; 7) Patients or family members who can understand the research plan and are willing to participate in the research, and sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. Malignant tumors at the same time or at different times (within 5 years); 2. Patients with intestinal obstruction, intestinal perforation, intestinal bleeding, etc. who need emergency surgical resection; 3. Past history of colorectal surgery, which may affect patients with this digestive tract reconstruction; 4. It is expected that more than 2 organs will be removed together; 5. ASA IV or V level; 6. Pregnant or lactating women; (1) Women of childbearing age have a positive pregnancy test at baseline or have not received a pregnancy test. Postmenopausal women must be at least 12 months after menopause; (2) Men or women who are sexually active (childbearing age) are unwilling to use contraception during the trial. 8. Severe mental illness; 9. Severe emphysema, interstitial pneumonia or ischemic heart disease who cannot tolerate surgery; 10. Continuous systemic steroid therapy within 1 month; 11. The patient has contraindications to laparoscopic surgery; 12. Past trauma or operation history of pelvic fracture; 13. Allergy to the contrast agent iopromide; 14. History of pelvic radiotherapy, or preoperative staging assessment requiring neoadjuvant therapy; 15. Patients or family members cannot understand the conditions and goals of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Local recurrence rate;Complication rate after surgery; | — |
Countries
China
Contacts
Public ContactXiaohui Shi
The First Affiliated Hospital of Naval Medical University
Outcome results
None listed