stroke
Conditions
Interventions
experiment group:Stimulation site determined by motor omagery based brain computer interface
control group:Classic low frequency rTMS
Sponsors
Huashan Hospital,Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Willing to sign informed consent; 2. Aged between 18 to 80 years old, male or female; 3. Diagnosis in accordance with the key criteria point rasied in Chinese Classification of Cerebrovascular Diseases 2015; 4. Confirmed by CT or MRI of the brain; 5. No cognitive impairment screened by MMSE; 6. No visual or auditory impairment; 7. Paretic wrist motor impairment, no active wrist motion and strength between 0-1; 8. Disease duration above 3 months; 9. Vital signs stable.
Exclusion criteria
Exclusion criteria: 1. The questionnaire survey on motor and visual imagery shows that motor imagery cannot be performed; 2. Those with severe cardiopulmonary, liver, and kidney dysfunction who are not suitable for rehabilitation training (in the past 6 months, due to any cause of congestive heart failure (CHF) attack or worsening. Any need to change the dosing regimen, diet or hospitalization Heart failure is the onset of CHF; known valvular heart disease with CHF; thoracotomy cardiac surgery (eg, coronary artery bypass, valve replacement); acute myocardial infarction in the past 3 months; acute urgency on admission Signs or symptoms of infarction, including electrocardiographic findings; suspected aortic dissection on admission; acute arrhythmia with hemodynamic instability (including any tachycardia or bradycardia), etc.; liver dysfunction (Gu Bing, Asparagus is more than 1.2 ULN); blood creatinine and urea nitrogen are more than 1.2 ULN; existing acute or chronic lung disease); poor blood pressure and blood glucose control, blood pressure is detected as systolic blood pressure >= 140mmHg, diastolic blood pressure >= 90mmHg; 3. Patients with metal in the body (pacemaker, arterial stent, etc.), cannot complete MRI examination; 4. Pregnant or lactating women; 5. Poor compliance and unable to complete this training; 6. Those who participated in other clinical trials at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AROM of paretic wrist; | — |
Secondary
| Measure | Time frame |
|---|---|
| Brunnstrom (upper limb and hand);ARAT;Fugl Meyer for upper limb;Key muscle strength of upper limb;Key muscle tension of upper limb;ADL;SEMG of key muscles of upper limb;EEG;fMRI and DTI; | — |
Countries
China
Contacts
Public ContactLu Rongrong
Huashan Hospital, Fudan University
Outcome results
None listed