Application of ctDNA in detection of postoperative recurrence and metastasis of intrahepatic cholangiocarcinoma

Establishment of liquid biopsy technique based on ctDNA detection and its application in genotyping and postoperative recurrence and metastasis monitoring of intrahepatic cholangiocarcinoma

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000036418

Enrollment

Unknown

Registered

2020-08-23

Start date

2020-10-01

Completion date

Unknown

Last updated

2020-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intrahepatic cholangiocarcinoma

Interventions

Gold Standard:Imaging findings of recurrence and metastasis of intrahepatic and extrahepatic lesions(CT, MRI or PET-CT)

Index test:mutant&#32

gene&#32

with&#32

by&#32

ctDNAa&#32

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with intrahepatic cholangiocarcinoma underwent resection and confirmed by postoperative pathology; 2. Aged 18 to 80 years old; 3. Complete clinical data ncan be obtained before operation; 4. Able to understand the research plan and participate in the study voluntarily, and sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients who received radiotherapy, chemotherapy, targeted therapy, immunotherapy and surgery before surgery; 2. Patients with recurrent intrahepatic cholangiocarcinoma; 3. Patients with serious postoperative complications; 4. Patients with previous history of malignancy in other organs; 5. Psychotic, drug abusers and pregnant or lactating women.

Design outcomes

Primary

Measure	Time frame
sensitivity;Specificity;	—

Countries

China

Contacts

Public ContactGeng Li

Eastern Hepatobiliary Surgery Hospital

gengliehbh@sina.com+86 13386270589

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026