Hypospadias
Conditions
Interventions
Experimental group:In the first stage of operation, UDC-Exos was smeared on the outer surface of prepuce or oral mucosa, and then the prepuce or oral mucosa was fixed on the ventral surface of penile
Control group:In the first stage of operation, placebo (saline) was smeared on the outer surface of prepuce or oral mucosa, and then the prepuce or oral mucosa was fixed on the ventral surface of peni
Sponsors
Children's Hospital of Shanghai
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Children with severe hypospadias who need to undergo staged operation using autologous prepuce or oral mucosa as urethral reconstruction materials, and their guardians should have informed consent.
Exclusion criteria
Exclusion criteria: Patients with DSD (dysplasia of sexual development). Patients with other external genitalia abnormalities.Patients who could complete hypospadias surgery in one stage. Patients' guardians refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Repair effect of corpus spongiosum defect; | — |
Secondary
| Measure | Time frame |
|---|---|
| Surgical effect and postoperative complications of hypospadias; | — |
Countries
China
Contacts
Public ContactFang Chen
Children's Hospital of Shanghai
Outcome results
None listed