Brain metastasis of NSCLC
Conditions
Interventions
conventional group:Surgery+conventional therapy(Radiotherapy)
novel group:Surgery+Targeted/immune therapy
Sponsors
Huashan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with non-small cell lung cancer diagnosed; 2. Imaging of brain metastases, patients with lesion size > 1.5cm * 1.5cm * 1.5cm; 3. Patients who had no operation contraindication and underwent total resection of metastatic tumor; 4. Patients with NSCLC brain metastases confirmed by pathology; 5. Subjects with or without other treatments (radiotherapy, targeted therapy, immunotherapy); 6. Patients aged over 18 years and less than 65 years, both male and female; 7. Subjects signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of other primary tumors; 2. Patients with primary brain diseases: encephalitis, meningoencephalitis, brain parasite infection, brain trauma, massive cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage; 3. Patients with severe cardiopulmonary disease: COPD, interstitial pneumonia, coronary heart disease, heart failure; 4. Patients with abnormal liver and kidney function: serum creatinine >= 1.25 times of normal upper limit, creatinine clearance rate = 1.5 times of normal upper limit, AST and alt >= 2.5 times of normal upper limit; 5. Pregnant or lactating objects; 6. Subjects participated in other clinical studies at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PFS;OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| annual survival rate; | — |
Countries
China
Contacts
Public ContactXu Hongzhi
Huashan Hospital Affiliated to Fudan University
Outcome results
None listed