Colorectal cancer
Conditions
Interventions
Control group:Empirical systemic standard regimen neoadjuvant chemotherapy (FolFox)
Experimental group:Paclitaxel intraperitoneal chemotherapy combined with systemic standard regimen for neoadjuvant chemotherapy
Sponsors
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Colorectal and peritoneal metastatic adenocarcinoma was confirmed by pathology; 2. Aged >=18 years old; 3. ECOG score 0-1; 4. Body Mass Index (BMI, Body Mass Index) 18-30kg/m2. 5. PCI score > 15 6. Before starting chemotherapy, the white blood cell and platelet count should not be lower than the lower limit of normal, and the creatinine and total bilirubin should not be higher than the upper limit of normal 7. Before the start of the study, the patient himself or the authorized client signed the informed consent form and agreed to be included in the study
Exclusion criteria
Exclusion criteria: 1. Those who have undergone CRS; 2. Patients with previous history of intraperitoneal chemotherapy; 3. Suffered from malignant tumors in the past 5 years, but excluding other skin malignancies other than malignant melanoma, cervical carcinoma in situ, and stage 1A endometrial cancer; 4. There were other metastasis except lymph node and peritoneum; 5. Pregnant or breastfeeding women; 6. Patients who have received neoadjuvant radiotherapy and chemotherapy; 7. Patients who are allergic to the drugs involved in the study; 8. Patients whose abdominal cavity has severe adhesions confirmed by surgery or other means and cannot undergo abdominal chemotherapy; 9. Patients whose life expectancy does not exceed 12 weeks; 10.Patients who were assessed to have contraindications to intraperitoneal chemotherapy; 11. Refusing to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Response Rate;progression-free survival, PFS; | — |
Countries
China
Contacts
Public ContactJing Sun
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed