melasma
Conditions
Interventions
LED phototherapy group:LED 585nm wavelenth, power density 20mW/cm2,Treatment time:1000 seconds(Total energy density: 20J/cm2)
control group:Kligman–Willis formula (5% hydroquinone, 0.1%tretinoin, 0.1% dexamethasone)
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who sign informed consent and are willing to complete the study according to the protocol; 2. Patients aged 18-65 years with melasma; 3. Patients with Fitzpatrick skin type of III to IV.
Exclusion criteria
Exclusion criteria: 1. Patients with history of heart disease, liver disease and kidney disease; 2. patients with mental disorders or unable to cooperate with the treatment of patients; 3. Pregnant or lactating women; 4. Patients who had received topical treatment (2% hydroquinone cream, 0.025% tretinoin ointment, chemical stripping of fruit acid, topical and local injection of tranexamic acid) or oral tranexamic acid tablets within the first two weeks before inclusion in the study; 5. Patients with vitiligo or other pigmentation diseases or family history; 6. Patients who may be allergic to visible light; 7. Patients who may be allergic to hydroquinone or retinoic acid or topical dexamethasone; 8. Patients who participated in other clinical trials recently; 9. Patients who are not suitable for this trial which was judged by clinical trial researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mMASI score;scores of brown spots; | — |
Secondary
| Measure | Time frame |
|---|---|
| Malanin Index;Erathema Index;transepidermal waterloss, TEWL;objective evaluation of clinical photographs;satisfaction rating from subjects;observation and recording of side effects; | — |
Countries
China
Contacts
Public ContactChengfeng Zhang
Huashan hospital, Fudan University
Outcome results
None listed