Cirrhosis
Conditions
Interventions
Hospitalized cirrhosis with bacterial/fungal infection:non-interventional
Hospitalized cirrhosis without bacterial/fungal infection:non-interventional
Sponsors
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
16 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Inpatient with cirrhosis as confirmed either by the histological scoring system, imaging finding of nodular liver (abdominal Ultrasound, CT or MRI), endoscopic findings of esophageal varices or a combination of biochemical and clinical manifestation; 2. Admitted for at least one of the following reasons: (1) Bacterial infection/fungal infection; (2) Overt Ascites (Grade II-III); (3) Gastrointestinal bleeding; (4) Hepatic encephalopathy; (5) Jaundice (Total bilirubin >=5 mg/dL) with coagulation dysfunction (INR >=1.5).
Exclusion criteria
Exclusion criteria: 1. Age below 16 or over 80 years; 2. Lactation/ Pregnancy women; 3. HIV infection; 4. Admitted for scheduled procedures (e.g., band ligation, splenectomy, transjugular intrahepatic portosystemic shunting, liver biopsy) or re-examination or multidisciplinary consultation); 5. Hepatocellular carcinoma (HCC) outside Milan criteria or other disseminated malignancies; 6. Previous liver transplantation; 7. With previously known severe extra-hepatic diseases (e.g., chronic renal failure requiring hemodialysis, severe heart disease; severe chronic pulmonary disease, psychiatric disorders); 8. Taking immunosuppressive or anticoagulation drugs for the treatment of extra-hepatic disease; 9. Patient' s refusal to participation; 10. Failure to provide prior informed consent or with documented evidence that the patient has no legal surrogate decision maker and it appears unlikely that the patient will regain consciousness or sufficient ability to provide delayed informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transplant-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Transplant-free survival;Overall survival;Prevalence of organ failure, AKI, ACLF; | — |
Countries
China
Contacts
Public ContactQing Xie
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed