Detection of chromosome copy number variation and point mutation in acute lymphoblastic leukemia based on MLPA-NGS

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000036357

Enrollment

Unknown

Registered

2020-08-22

Start date

2020-10-01

Completion date

Unknown

Last updated

2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Lymphoblastic Leukemia

Interventions

Gold Standard:The diagnosis of leukemia depends on the combination of flow cytometry, cell morphology, karyotype analysis, fish, aCGH, SNP chip and quantitative PCR.

Index test:MLPA-NGS Technology

Eligibility

Sex/Gender

All

Age

2 Years to 18 Years

Inclusion criteria

Inclusion criteria: According to the guidelines of "Diagnostic and therapeutic criteria for childhood acute lymphoblastic leukemia (2018 Edition)", patients with childhood acute lymphoblastic leukemia were judged by morphological, immunophenotypic and cytogenetic tests.

Exclusion criteria

Exclusion criteria: Patients who were not diagnosed with childhood acute lymphoblastic leukemia; and those who were not willing to participate in this study.

Design outcomes

Primary

Measure	Time frame
Morphology;cytochemical stain;Immunology;Cytogenetics;Molecular biology;routine blood test;Biochemical examination;Coagulation function;Imaging examination;	—

Countries

China

Contacts

Public ContactYang Yongchen

Shanghai Children's Hospital

yangyongchen@aliyun.com+86 13166289594

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026