Necrotizing enterocolitis
Conditions
Interventions
RIC group:Remote ischemic conditioning
Control group:No RIC intervention
Sponsors
Children's Hospital of Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Gestational age less than 36 weeks; 2. Weight equal or more than 750 g; 3. Infants with NEC stage I according to Modified Bell's Classification (medically treated cases with no need of surgical intervention at time of enrollment); 4. Patients whose parents consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Patients with major congenital heart disease (requiring surgical repair); 2. Patients with major congenital anomalies of gastrointestinal system; 3. Hemodynamically unstable patients (defined as neonates who are on > 2 medications to support blood pressure); 4. With antecedent of limb ischemia/limb thrombotic events; 5. With antecedent diagnosis of occlusive arterial or venous thrombosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Surgical intervention rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality rate;Duration of parenteral nutrition;Time at reintroduction of enteral feeds;Time to full enteral feeds;Type of operation;Length of small and large intestine resected;Length of retained intestine;Number and type of inotropic support;Type and duration of ventilatory support;Number of recurrent NEC episodes; | — |
Countries
China
Contacts
Public ContactHaitao Zhu
Children's Hospital of Fudan University
Outcome results
None listed