Colon cancer
Conditions
Interventions
Group A:Radical surgery+Targeted drugs
Group B:Local excision
Sponsors
Fudan University Shanghai Cancer Center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years old; 2. Pathologically confirmed pT1 colon cancer patients; 3. ECOG performance status of 0 to 2; 4. ASA score of 1 to 2; 5. Adequate bone marrow, liver and renal function to receive chemotherapy and subsequently to undergo surgery: (1) white blood cells >3,000/uL, absolute neutrophil count >=1,500/UL, platelets >=100,000/uL, hemoglobin >=9 g/dL; (2) serum creatinine =60 mL/min according to Cockroft-Gault formula or to local lab measurement; (3) serum bilirubin <1.25 UNL, AST(SGOT) and ALT(SGPT) <2.5 UNL; 6. Comply with the study protocol and follow-up; 7. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. Synchronous or metachronous (within 5 years) malignancy other than carcinoma in situ; 2. Any other concurrent medical conditions contraindicating surgery or chemotherapy that could compromise the adherence to the protocol; 3. Other conditions, such as religious, psychological and other factors, that could interfere with provision of informed consent, compliance to study procedures, or follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AE;SAE;Overall Survival;Progression-Free Survival; | — |
Countries
China
Contacts
Public ContactDawei Li
Fudan University Shanghai Cancer Center
Outcome results
None listed