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Study on the application of prostate cancer bone metastasis organoid model in individualized drug screening

Study on the application of prostate cancer bone metastasis organoid model in individualized drug screening

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000036347
Enrollment
Unknown
Registered
2020-08-22
Start date
2020-12-01
Completion date
Unknown
Last updated
2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

prostate cancer

Interventions

Gold Standard:Clinical outcomes: PSA-related biochemical-progression-free survival (bPFS), radiology progression-free survival (rPFS), cancer-specific survival (CSS)
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Sponsors

Huashan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
50 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Suspected prostate cancer patients with clinical high-risk factors (such as serum prostate specific antigen level >=20ng/ml); 2. Received prostate magnetic resonance scan before puncture; 3. Agree to undergo prostate biopsy; 4. Agree to continue to receive treatment and follow-up in our hospital after diagnosis; 5. After diagnosis, patients need to receive any form of endocrine therapy (including neoadjuvant endocrine therapy, adjuvant endocrine therapy, systemic therapy based on endocrine therapy or endocrine therapy combined with cytotoxic drug chemotherapy) based on the assessment of the condition; 5. Sign informed consent.

Exclusion criteria

Exclusion criteria: 1. The patient refused to undergo a prostate biopsy; 2. The patient refused to continue to receive treatment and follow-up in our hospital after the diagnosis; 3. After the patient is diagnosed, according to the tumor stage and grade, it is found that it meets the indications for radiotherapy and the patient needs to receive radiotherapy.

Design outcomes

Primary

MeasureTime frame
PSA-related biochemical-progression-free survival;radiology progression-free survival;

Secondary

MeasureTime frame
cancer-specific survival;

Countries

China

Contacts

Public ContactLimin Zhang

Huashan Hospital, Fudan University

alexzlm1126@126.com+86 13917445378

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026