Acute kidney injury
Conditions
Interventions
control:regular D-Na
Experimental group:adjust D-Na to Na-optimum
observation group:none
Sponsors
Shanghai General Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The first part of this study plans to prospectively include AKI patients hospitalized in 6 centers Specific inclusion criteria are as follows: (1) The age of the subjects are more than 18 years old and less than 75 years old.; (2) Diagnostic criteria for patients with AKI (KDIGO AKI definition in 2012): one of the following: I. Scr increased more than 26.5 umol/L within 48 hours; II. Scr increased more than 1.5 times the baseline - confirmed or speculated to occur within 7 days; III. Urine volume < 0.5 ml/(kg.h), and lasted more than 6 hours. Obstructive nephropathy or dehydration were excluded. (3) The patients voluntarily agree to participate in the study and sign the informed consent; 2. Part 2 of this study is going to prospectively include patients with AKI who received PIRRT in two centers The specific inclusion criteria are as follows: (1) The age of the subjects are more than 18 years old and less than 75 years old; (2) Diagnostic criteria for patients with AKI (KDIGO AKI definition in 2012): one of the following: 1) Scr increased more than 26.5 umol/L within 48 hours; 2) Scr increased more than 1.5 times the baseline - confirmed or speculated to occur within 7 days; 3) Urine volume < 0.5 ml/(kg.h), and lasted more than 6 hours. Obstructive nephropathy or dehydration were excluded. (3) The patients voluntarily agree to participate in the study and sign the informed consent; (4) receive prolonged intermittent renal replacement therapy.
Exclusion criteria
Exclusion criteria: 1. The first part of this study plans to prospectively include AKI patients hospitalized in 6 centers Specific exclusion criteria are as follows: (1) Patients had been diagnosed with chronic kidney disease (CKD) stage 5 or had received dialysis treatment before AKI; (2) Pregnant and lactating women; (3) extreme serum sodium level, referring to blood sodium 170.0mmol/L. 2. Part 2 of this study is planned to prospectively include patients receiving PIRRT for AKI in two centers Specific exclusion criteria are as follows: (1) Patients had been diagnosed with stage 5 chronic kidney disease (CKD) or had received dialysis treatment before AKI occurred; (2) Pregnant and lactating women; (3) AKI patients who received other renal replacement therapy modes; (4) Previous history of kidney transplantation; (5) Terminally ill or in danger of death within 48 hours; (6) extreme value of serum sodium level, refers to blood sodium 170.0mmol/L.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum sodium;serum creatinine; | — |
Countries
China
Contacts
Public ContactShu Rong
Shanghai General Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed