knee osteoarthritis/ knee rheumatoid arthritis
Conditions
Interventions
B:Drug composition of local infiltration around the joint is: Ropivacaine and dexmedetomidine
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) patients requiring unilateral initial TKA surgery due to severe knee osteoarthritis or rheumatoid arthritis; (2) aged 18 to 80 years; (3) body mass index was 20~35 kg/m2; (4) the American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) is I ~ II level.
Exclusion criteria
Exclusion criteria: (1) allergic to anesthetic drugs and sulfa; (2) there were more than moderate intraoperative knee malformations (pronation and flexion malformations) and joint stiffness; (3) alcoholic or long-term opioid users; (4) language impairment and inability to perform pain numerical scales (NRS); (5) surgical limb neuropathy; (6) mental patients; (7) patients with previous sick sinus syndrome, severe sinus bradycardia(Heart rate < 50 beats/min) or severe atrioventricular block (type III).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative dosage of remedial morphine hydrochloride;Time of first postoperative analgesia;VAS pain score;QoR-15 score;Range of knee motion;Quadriceps strength;Daily walking distance;Incidence of postoperative complications;Time to first straight leg raise;The duration of hospital stay;inflammatory factor;AIS score; | — |
Countries
China
Contacts
Public ContactZongke Zhou
West China Hospital, Sichuan University
Outcome results
None listed