Bronchiectasis
Conditions
Interventions
Control Group:Symptomatic treatment with conventional phlegm drugs
Experimental Group:Oral vitamin D in addition to conventional phlegm drugs
Sponsors
Shanghai Chest Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Patients aged 18-75 years with clinical diagnosis of branch expansion (confirmed by chest HRCT scan); 2) The patients with bronchiectasis are in a stable phase (the respiratory symptoms have not changed significantly compared with usual for 4 consecutive weeks, and there has been no acute exacerbation of bronchiectasis or acute upper respiratory infection); 3) The forced expiratory volume in the first second (FEV1) >= 30% of the predicted value.
Exclusion criteria
Exclusion criteria: 1) Patients with cystic fibrosis; 2) Those who are known to be allergic to vitamin D; 3) Combined with bronchial asthma, pulmonary aspergillosis, or active tuberculosis, or active non-tuberculous mycobacterial infection; 4) Combined with a history of severe cardiovascular, liver, kidney, hematopoietic and neurological diseases, etc.; 5) Combined with serious systemic diseases and mental disorders; 6) Diabetic patients with poor control or fasting blood glucose > 10mmol/L 7) Combined with active gastric ulcer or moderate to severe reflux esophagitis; 8) Malignant tumors; 9) Chronic respiratory failure and long-term use of non-invasive mechanical ventilation or oxygen therapy (>10 hours per day); 10) Pregnant or lactating women or women of childbearing age who are about to conceive; 11) Long-term oral administration of vitamin D or calcium or other drugs that affect the metabolism of vitamin D before enrollment; 12) Those who need oral or intravenous glucocorticoid therapy, or use systemic hormones within 30 days before enrollment. 13) In the past 6 months, treatment with macrolides has exceeded 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Leicester Cough Questionnaire;Bronchiectasis Patient Health Questionnaire;Acute exacerbations;Serum 25 (OH) D level; | — |
Countries
China
Contacts
Public ContactZhang Hai
Shanghai Chest Hospital
Outcome results
None listed