Nonalcoholic fatty liver disease
Conditions
Interventions
normal group:none
Sponsors
Department of Thyroid Biliary Deweighting and Metabolic Surgery, the Fourth Clinical College Affiliated to China Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: NAFLD group: 1. Meet the clinical, pathological or imaging diagnostic criteria for nonalcoholic fatty liver disease. 2. Meet the indications for metabolic surgery, and sign the informed consent. 3. Understand and agree to conduct intraoperative liver biopsy in the surgery, and agree to keep the biological sample in the biobank for the remaining liver tissue, fat tissue and blood after normal pathological diagnosis and treatment. 4. 18 to 60 years old (including values at both ends) at the time of signing the informed consent. 5. Able to understand and sign the informed consent. If illiterate, press the handprint. Normal group: 1. Consistent with the indications for the cholecystectomy. 2. After cholecystectomy, there was residual liver tissue on the specimen surface. 3. At the time of signing the informed consent, the person shall be at least 18 to 60 years old (including values at both ends). 4. Able to understand and sign the informed consent. If illiterate, press the handprint.
Exclusion criteria
Exclusion criteria: NAFLD group: 1. There are other liver diseases that can cause the fatty liver, including Autoimmune liver disease, drug liver injury (DILI), viral hepatitis, metabolic liver disease, Wilson's disease, alpha-1 antitrypsin deficiency and other diseases. 2. Patients with liver malignant tumor, biliary tract infection and other diseases, and use of drugs that may cause abnormal ALT, AST, GGT, etc. related to serum liver function previously or currently. 3. Patients with serious organic diseases, such as heart disease, and malignant tumors. 4. Patients with a history of long-term heavy drinking, male: alcohol intake was >30g/day (female: alcohol intake was > 20g/day). 5. The researchers considered the patients unsuitable for the study. Normal group: 1. Exclude various liver diseases that can cause the fatty liver, including non-alcoholic fatty liver, alcoholic fatty liver, Autoimmune liver disease, DILI, viral hepatitis, metabolic liver disease, Wilson's disease, alpha-1 antitrypsin deficiency and other diseases. 2.Patients with liver malignant tumor, biliary tract infection and other diseases, and use of drugs that may cause abnormal ALT, AST, GGT, etc. related to serum liver function previously or currently. 3. Patients with serious organic diseases, such as heart disease, and malignant tumors. 4. Patients with a history of long-term heavy drinking, male: alcohol intake was > 30g/day (female: alcohol intake was > 20g/day). 5. The researchers considered the patients unsuitable for the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| adiponectin;Nrf2;hepatic mitochondrial ß-oxidation; | — |
Countries
China
Contacts
Public ContactYong Wang
The Fourth Affiliated Hospital of China Medical University
Outcome results
None listed