Morbid obesity
Conditions
Interventions
Group of SADI-S:SADI-S Surgery
Group of SG:SG Surgery
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1)Aged 18 to 60 years; 2)Body mass index (BMI) >= 37.5 kg / m2; 3) Willing and able to comply with the research procedures stipulated in the protocol; and 4) Able to understand and sign informed consent.
Exclusion criteria
Exclusion criteria: 1) The medical history of T2DM lasts more than 15 years; 2) A history of drug and/or alcohol abuse within 2 years before the screening visit; 3) Have previously received any major gastrointestinal surgery (for example, any gastrointestinal surgery for resection, etc.). Allow history of past gastrointestinal surgery including: appendectomy, cholecystectomy, liver biopsy and endoscopic surgery; 4) Women of childbearing age who are pregnant or breastfeeding during screening and surgery, or plan to become pregnant within one year after surgery; 5) Mental diseases that may affect compliance with clinical research, including dementia, active psychosis, severe depression, or attempted suicide; 6) Inflammatory diseases of the gastrointestinal tract, including severe refractory esophagitis, gastric ulcer, duodenal ulcer, or specific inflammation that has been active in the past 10 years, such as Crohn's disease or ulcerative colitis; 7) End-stage renal disease, glomerular filtration rate <15ml/min/1.73m2; 8) Glutamate decarboxylase antibody (GADA), protein tyrosine phosphatase antibody (IA-2A) is abnormal; 9) Immune function is low, such as caused by long-term oral steroid hormones, cancer chemotherapy drugs, or immunodeficiency diseases; 10) Participate in any other clinical research (except registration or investigative research) within 30 days before Visit 1 (screening visit), or during the research process.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| %TWL; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting Plasma Glucose;HbA1c;LDL-c;Blood pressure;Waist Circumstance; | — |
Countries
China
Contacts
Public ContactBao Yuqian
Shanghai 6th People's Hospital
Outcome results
None listed