Advanced adenocarcinoma lung cancer
Conditions
Sponsors
Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Those who meet the diagnostic criteria for primary bronchopulmonary carcinoma, histologically or cytologically confirmed as adenocarcinoma, with EGFR 21 exon L858R and EGFR 19 exon deletion mutations identified by Arm method or second generation sequencing. (2) Patients with non-surgical carriers of stage IIIB-IV NSCLC according to international staging criteria, or patients with carriers who have undergone surgery but have not undergone radical resection, or patients with recurrent postoperative metastases with objectively assessable tumor foci. (3) Aged between 18 and 80 years at the time of diagnosis of primary bronchopulmonary cancer. (4) After 1 month of taking icotinib, for patients whose TCM diagnosis belongs to Qi deficiency or Qi and Yin deficiency, the clinical diagnosis shall be confirmed by two or more attending physicians respectively. (5) Have not received any prior systemic treatment. (6) Survival is expected to be >= 6 months. (7) Physical condition score ECOG PS = 1.5x10^9/L, platelet>=80x10^9/L, no obvious abnormalities in liver and kidney function. (9) Willingness to accept the pilot programme and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Lack of objective evaluation of the tumour foci. (2) Those with an acute infection that has not been controlled, or with septic and chronic infections that have persistent wounds. (3) Persons who have used antipyretic or adrenocorticosteroid medications within 1 week, or who have taken oral pain medications containing NSAIDs for long-term pain control. (4) Refusal to accept this trial protocol. (5) Patients with symptomatic brain metastases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life scale score;PS;TCM clinical symptom score;Adverse reactions;immune function; | — |
Countries
China
Contacts
Public ContactShen Liping
Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed