sepsis
Conditions
Interventions
high inflammation group:Methylprednisolone 40 mg twice a day for 5 days or until out of ICU or death
immunosuppression group:One alpha thymosin peptide once a day for 5 days or until out of ICU or death
low inflammation group:no intervention
no immunosuppression:no intervention
Sponsors
Renji Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 79 Years
Inclusion criteria
Inclusion criteria: 1. Meet sepsis 3.0 diagnostic criteria (clinically clear infection and SOFA >= 2 points); 2. Aged >= 18 years, no gender limit; 3. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Aged > 80 years; 2. HIV infection; 3. Receiving anti-tumor chemotherapy in the last three months; 4. Being receiving immunosuppressive treatment due to organ transplantation and immune diseases; 5. Allogeneic bone marrow suppression or stem cell transplantation; 6. Use hormone therapy in the past three months (0.5mg/kg prednisone or equivalent other hormones for more than 30 days).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| M1/M2/Mreg level;Key RNA levels in macrophages;Existing clinical immune function indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| APACHE II score;SOFA; | — |
Countries
China
Contacts
Public ContactYuan Gao
Renji Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed