Therapeutic effect of rTMS on elderly patients with first-episode depression and the biological mechanism of its influence on specific cognitive function

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000036188

Enrollment

Unknown

Registered

2020-08-21

Start date

2020-09-01

Completion date

Unknown

Last updated

2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

First episode depression in the elderly

Interventions

Group 1: rTMS-20HZ

Group 2:rTMS-iTBS

Group 3:sham stimulation

Eligibility

Sex/Gender

All

Age

60 Years to 90 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients with first-episode depression during old age. All researchers were required to complete cognitive assessment before rTMS treatment. Participants: each ward of Shanghai Mental Health Center, support program cohort study and Shanghai Brain Health cohort study. The specific criteria were as follows: 1) Aged >= 60 years; 2) meeting the diagnostic criteria of DSM-IV depression; 3) geriatric GDS > 10 points.

Exclusion criteria

Exclusion criteria: 1) physical diseases related to depression, or previous neurological diseases related to depression; 2) bipolar disorder; 3) epilepsy; 4) severe head trauma or brain surgery; 5) implantation of metal objects (except braces); 6) implantation of cardiac pacemakers or other stimulators; 7) pregnancy; 8) first-episode depression in non senile period; to reduce suicide risk The subjects of this project can be combined with antidepressants and psychotherapy.

Design outcomes

Primary

Measure	Time frame
Depression improvement;	—

Secondary

Measure	Time frame
COMT;ApoE;MRI;	—

Countries

China

Contacts

Public ContactWei Li

Shanghai Mental Health Center

822203867@qq.com+86 15000033653

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026