psoriasis
Conditions
Interventions
Acitretin treatment group:Acitretin
MTX treatment group:MTX
NB-UVB treatment group:NB-UVB
Biologics Group:Biologics
Sponsors
Shanghai Skin Disease Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) The age of the patient is 18-65 years old, regardless of gender. (2) Patients with diagnosed moderate to severe plaque psoriasis: course of disease >= 6 months, BSA > 10% and PASI > 10 at screening; (3) Have not received systemic treatment (Acitretin, cyclosporine, ultraviolet light therapy, methotrexate, etc.) within the last month, and have not received topical medication (vitamin D3 derivatives, tretinoin, etc.) within the last 2 weeks Drugs, glucocorticoids, calcineurin inhibitors, etc.), and the researchers believe that the patient is suitable for treatment. (4) The patient voluntarily signs the informed consent and can be followed up on schedule.
Exclusion criteria
Exclusion criteria: (1) Patients suffering from other active skin diseases may affect the evaluation of the condition. (2) Abnormal laboratory examination: During screening, hemoglobin (Hb) was less than 80% of the lower limit of normal value. The white blood cell count in peripheral blood is less than 4.0 x 10^9/L, or more than 12 x 10^9/L. The neutrophil count in peripheral blood is less than 1.5 x 10^9/L. Platelets are less than the lower limit of normal. Liver function (any one of ALT and TBil) > 2 times the upper limit of normal; if abnormal, a review is allowed. Renal function (serum creatinine sCr) > 2 times the upper limit of normal. (3) Suffering from serious, progressive, uncontrolled diseases of important organs and systems (including cardiovascular, liver, lung, and kidney), other autoimmune diseases, malignant tumors, and the researchers belief that there are complications Other diseases suitable for participating in this study. (4) A history of severe allergic reactions. (5) Received systemic treatment within 1 month before screening; received topical medication within 2 weeks before screening. (6) Women who are pregnant, breastfeeding and planning to become pregnant within one year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| psoriasis area and severity index ; | — |
Countries
China
Contacts
Public ContactYuling Shi
Shanghai Skin Disease Hospital
Outcome results
None listed