Research of individual non-depolarizing muscle relaxant medication regimen for patients with high percentage body fat

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000036171

Enrollment

Unknown

Registered

2020-08-21

Start date

2020-08-14

Completion date

Unknown

Last updated

2020-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High percentage body fat

Interventions

1:Dosing according to total body weight

2:Dosing according to Fat free mass

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective surgery under general anesthesia; 2. Aged 18 to 65 years, ASAI-II grade, BMI19-28kg/m2, body fat rate> 25%; 3. Sign informed consent.

Exclusion criteria

Exclusion criteria: 1. History of muscle relaxant allergy, use of drugs that affect the pharmacodynamics of muscle relaxants (anti-epileptic, aminoglycoside antibiotics, etc.) within one week before surgery; 2. Heart, brain, liver, lung, kidney, endocrine diseases or neuromuscular transmission function decline or disorder, acid-base imbalance or electrolyte imbalance; 3. Surgical patients with high requirements for muscle relaxation (abdominal surgery, laparoscopic surgery); 4. Intraoperative use of antibiotics that may affect the efficacy of muscle relaxation drugs.

Design outcomes

Primary

Measure	Time frame
percentage body fat;TOF;Blood concentration of the drug;PORC;Diaphragm movement;	—

Secondary

Measure	Time frame
Height;weight;age;HR;MAP;time to extubate;incidence of tongue drop;	—

Countries

China

Contacts

Public ContactGuanghui An

Shanghai General Hospital

gh_An@163.com+86 13764122642

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026