Effects of dexmedetomidine on periarticular infiltration analgesia in total hip arthroplasty: a prospective, double-blind, randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000036164

Enrollment

Unknown

Registered

2020-08-21

Start date

2021-01-01

Completion date

Unknown

Last updated

2020-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis/ knee rheumatoid arthritis

Interventions

A:Drug composition of local infiltration around the joint: Ropivacaine

B:Drug composition of local infiltration around the joint is: Ropivacaine and dexmedetomidine

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Patients requiring unilateral initial THA surgery due to severe hip osteoarthritis, rheumatoid arthritis or femoral head necrosis; (2) Aged 18 to 80 years; (3) Body mass index was 20~35 kg/m2; (4) The American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) is I ~ II level.

Exclusion criteria

Exclusion criteria: (1) Allergic to anesthetic drugs and sulfa; (2) There were more than moderate intraoperative hip malformations and joint stiffness; (3) Alcoholic or long-term opioid users; (4) Language impairment and inability to perform pain numerical scales (NRS).

Design outcomes

Primary

Measure	Time frame
Postoperative dosage of remedial morphine hydrochloride;Time of first postoperative analgesia;VAS pain score;Range of hip motion;Daily walking distance;Incidence of postoperative complications;The duration of hospital stay;inflammatory factor;AIS score;	—

Countries

china

Contacts

Public ContactZongke Zhou

West China Hospital, Sichuan University

zhouzongke@scu.edu.cn+86 18980601028

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026