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A multicenter randomized controlled clinical study of Chuanhuang prescription combined with reduced glutathione regimen in the treatment of patients with 1-2 grade AKI on the basis of 2-4 stage CKD and its clinical evaluation of early diagnostic markers

A multicenter randomized controlled clinical study of Chuanhuang prescription combined with reduced glutathione regimen in the treatment of patients with 1-2 grade AKI on the basis of 2-4 stage CKD and its clinical evaluation of early diagnostic markers

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000036162
Enrollment
Unknown
Registered
2020-08-21
Start date
2020-10-05
Completion date
Unknown
Last updated
2020-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A on C

Interventions

Sponsors

Shanghai Municipal Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. It meets the diagnostic criteria of stage CKD2-4 and stage 1-2 of acute kidney injury; 2. Meet the criteria for TCM syndrome diagnosis of deficiency of spleen and kidney and mutual knot of toxin and blood stasis; 3. 24 hU - pro 2.5 grams or less; 4. Aged between 18 and 75; 5. Patients who voluntarily participate in this clinical trial and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. pregnancy or preparation for pregnancy and breast-feeding women; 2. complicated with serious primary diseases with other organs in urgent need of immediate treatment, or with malignant tumors, active tuberculosis and other consumption system diseases; 3. after renal transplantation; 4. mentally ill, unable to cooperate; 5. allergic to therapeutic drugs; 6. participants in other drug clinical trials or in other clinical trials within 3 months.

Design outcomes

Primary

MeasureTime frame
Serum creatinine;Blood urea nitrogen;eGFR;24h U-pro;Acr;IL-6;TNF-a;HO-1;MDA;SOD;Blood potassium;the syndrome scores of TCM;

Countries

China

Contacts

Public ContactGong Xuezhong

Shanghai Municipal Hospital of Traditional Chinese Medicine

2071425786@qq.com+86 021-56639828

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026