postoperative neurocognitive disorder
Conditions
Interventions
experimental group:Perioperative probiotics intervention
control group:placebo
Sponsors
Jiaxing Second Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients who are intended to undergo orthopedic lower extremity surgery under general anesthesia; 2. Aged >= 65 years; 3. ASA grade I-III; estimated postoperative hospital stay >= 7 days; 4. Preoperative simple Intelligent Mental State Scale test was normal, 5. Normal speech communication. 6. The patient and family member are willing to participate in the trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. history of central nervous system disease, 2. cognitive impairment, 3. use of cognitive improvement drugs and probiotics, 4. visual and auditory impairment, 5. a history of alcohol abuse or drug dependence, 6. preoperative use of anticholinergic drugs, 7. frequently use of analgesics, 8. allergy to probiotics.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| daily life quality score;Postoperative delirium;Postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| KYN;ACh;BDNF;Fecal flora abundance;Genetic diversity of fecal flora;S100b;postoperative complications;hospital stays; | — |
Countries
China
Contacts
Public ContactJian Lu
Jiaxing Second Hospital
Outcome results
None listed