Biomarkers and multimodality MRI study of vascular cognitive impairment

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000036151

Enrollment

Unknown

Registered

2020-08-21

Start date

2020-10-01

Completion date

Unknown

Last updated

2020-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vascular cognitive impairment

Interventions

VaD:No

VCIND:No

NC:No

Eligibility

Sex/Gender

All

Age

18 Years to 90 Years

Inclusion criteria

Inclusion criteria: VCI inclusion criteria: 1. Aged >= 18 years old. 2. According to the diagnostic criteria of "probable vascular dementia (VAD)" proposed by NINDS-AIREN, and MMSE score 1 point; 5. HIS score > 4 points. The inclusion criteria of normal control group (NC): 1. Age matched with VCI group, normal neurological examination and independent behavior ability; 2. MMSE score >= 28; MOCA score >= 26; 3. CDR:0 Points. All the subjects had no contraindications to MRI examination and signed informed consent.

Exclusion criteria

Exclusion criteria: 1. There are aphasia, hearing, vision or dysarthria who can not complete the neuropsychological assessment; 2. Patients with severe heart, liver, lung and kidney diseases; 3. Patients with depression, anxiety or schizophrenia and other mental diseases; 4. Illiterate patients; 5. Patients with consciousness disorders, long-term drinking, severe head trauma history and other reasons can not cooperate with cognitive function examination.

Design outcomes

Primary

Measure	Time frame
MMSE;MoCA;Blood biochemical indexes;	—

Secondary

Measure	Time frame
Imaging features;	—

Countries

China

Contacts

Public ContactWang Hongmei

dd-tt12345@163.com+86 021-64369181-5404

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026