intrahepatic mass-forming cholangiocarcinoma
Conditions
Interventions
NLND:Hepatectomy
LND:Hepatectomy combined with regional lymph node dissection
Sponsors
Eastern Hepatobiliary Surgery Hospital Second, Military Medical University, Shanghai, China
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Pathologically diagnosis intrahepatic cholangiocarcinoma; above grade 2; without hilar invasion; stageT1-T2 assessed by AJCC 8th; No invasion of portal vein and main hepatic artery and free of extrahepatic metastasis; 2) Newly diagnosed patients without jaundice; 3) 18-85 years old, both sexes; 4) R0 resection; 5) Preoperative enhanced upper abdominal CT/MRI or PET-CT showed retroperitoneal lymph node negative or intraoperative diagnostic of suspected positive lymph nodes showed negative; 6) Normal functions of heart, liver and kidney; normal results of peripheral blood examination and electrocardiogram; without unhealed wound; Peripheral blood: WBC >= 3.0x10^9/L, PLT >= 80x10^9/L, Hb >= 90g/L; Renal function: Cr <= 2.0 x UNL (upper limit of normal); Liver function: Child A/B; ECOG PS: 0-2. 7) Sign ICF; good compliance, able to cooperate with experimental observation.
Exclusion criteria
Exclusion criteria: 1) With a history of other malignant tumors; 2) Have received chemotherapy, radiotherapy, immunotherapy or other treatments; 3) Liver dysfunction (upper gastrointestinal bleeding, hepatic encephalopathy) or Child C; 4) Positive retroperitoneal lymph node; 5) R1 or R2 resection; 6) Severe atherosclerosis; 7) The investigator believes that the patient should not participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| DFS;Safety;Proportion of regional lymph node metastasis; | — |
Countries
China
Contacts
Public ContactYongjie Zhang
Eastern Hepatobiliary Surgery Hospital Second, Military Medical University
Outcome results
None listed