Perioperative agitation
Conditions
Interventions
trial group:Sedation management with remimazolam
control group:Sedation management with dexmedetomidine
Sponsors
Sichuan Provincial Orthopedic Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients who have been removed endotracheal tube after fracture surgery and admitted to ICU for monitoring and treatment; 2. Aged >= 60 years, male or female; 3. Agitation-Sedation Scale (RASS) >= 1 point during ICU stay; 4. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Have a history of mental illness, or long-term use of sedative drugs, antipsychotic drugs and alcohol dependence; 2. Combined with craniocerebral trauma or intracranial diseases; 3. Severe allergic constitution, immune dysfunction or defects, or allergic to the drugs used in the program; 4. Combined or postoperative complications of severe cardiac dysfunction, severe liver and kidney dysfunction or severe obstructive pulmonary disease; 5. Combined with visual impairment, hearing impairment and other inability to communicate normally; 6. Patients who are currently participating in other drug studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to reach sedation target;Time to control agitation; | — |
Secondary
| Measure | Time frame |
|---|---|
| RASS scores before and after sedation;Use of sedative drugs;Incidence of delirium after agitation control;Total hospital stay;Duration of ICU stay;Hospital infection rate;Incidence of deep venous thrombosis; | — |
Countries
China
Contacts
Public ContactQin Zhijun
Sichuan Provincial Orthopedic Hospital
Outcome results
None listed