Late life depression
Conditions
Interventions
Experimental group:antidepressant+eaketamin
control group:antidepressant+saline
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >=60 years old, right-handed; 2. In line with the DSM-IV "major depressive disorder" diagnostic criteria, a sufficient course of treatment with at least two antidepressants in the past. A sufficient amount refers to the minimum effective dose, and a full course of treatment refers to the treatment of each of the above drugs for more than 4 weeks , Chronic depression needs to be treated for more than 8 weeks, and the depressive symptoms have not been significantly relieved (the reduction rate of the Hamilton Depression Scale is less than 30%) or the ATHF rating >=3; 3. The current HAMD-17 item >=17 points; 4. Agree to comply with the drug treatment plan required by this project during the research period; 5. The concomitant diseases before the baseline must remain clinically stable; 6. Educational level of elementary school and above, cooperate to complete the project test; 7. The subject or legal guardian agrees to participate in this study and signs an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Meet any other diagnostic criteria of DSM-IV axis I; 2. Hypothyroidism, vitamin B12 or folic acid deficiency, syphilis infection, stroke; 3. History of dementia, brain organic diseases, brain trauma or surgery; 4. Suffering from major physical diseases such as heart, liver, and kidney, cannot tolerate this study; 5. There were clear hallucinations and delusions before entering the group; 6. Have a history of substance or alcohol abuse; 7. Past history of ketamine allergy; 8. Received MECT, TMS treatment within three months; 9. Previous history of epileptic seizures; 10. Patients with angle-closure glaucoma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination;Magnetic Resonance Imaging; | — |
Countries
China
Contacts
Public ContactYuping Ning
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed